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Dose Titration & Meal Timing Slowly increase GLP1 doses and coordinate with meals to manage side effects, per your health care providers guidance 5

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CLINICAL TRIAL EVIDENCE FOR GLP-1 RAs IN MASH Table 2 provides a summary of phase 2 and phase 3 studies examining GLP-1 RAs and dual or triple agonists (aiming glucagon, GIP, and GLP-1 receptors) in individuals with MASLD/MASH, where hepatic biopsies were used to evaluate liver outcomes [3,5,10,11,15,22-25,44-52]

6 ng of cDNA was used for each reaction and all qPCR results were carried out in duplicate or triplicate, along with no template controls and no RT controls where appropriate

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